Immunosuppressive Activities of Fucoidan from Laminaria japonica

Effects of fucoidan from Laminaria japonica on 2,4-dinitrochlorobenzene induced delayed-type hypersensitivity (DTH) reaction and the serum levels of IgG, IgM, complement C3 and C4 were investigated in the present study. Results showed that oral administration of fucoidan at dose of 150 and 300 mg/(kg*d) for 9 days before the hapten challenge significantly inhibited 2,4-dinitrochlorobenzene induced delayed-type hypersensitivity reaction; and also inhibited the humoral immunity. Serum C3 and C4 levels were markedly reduced by fucoidan at dose of 150 and 300 mg/kg; and serum IgG and IgM levels were reduced by fucoidan at dose of 300 mg/kg. The inhibitory effects of fucoidan on delayed-type hypersensitivity suggested that it may be potential medication for chronic inflammatory diseases in the future.

作 者： 張全斌 李智恩 周革非 牛錫珍 張虹   作者單位： 張全斌,周革非(Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China;The Graduate School of Chinese Academy of Sciences, Beijing 100039, China)

李智恩,牛錫珍,張虹(Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China) 

刊 名： 中國海洋湖沼學報(英文版)  ISTIC SCI 英文刊名： CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY  年，卷(期)： 2003 21(4)  分類號： P7  關鍵詞： Laminaria japonica   fucoidan   delayed-type hypersensitivity   humoral immunity  

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