Improved Preparation of Tyramine by Curtius Rearrangement

An improved and facile preparation of tyramine [2-(p-hydroxyphenyl)ethylamine] was described, which starts from phenol and acrylonitrile to form β-(p-hydroxyphenyl) propionic acid via Friedel-Craft's alkylation and nitrile hydrolysis. After hydrazinolysis and a subsequent Curtius rearrangement, tyramine was obtained in 30.2% total yield.

作 者： LI Yun YANG Fan XU Xiaoying PAN Shiyin WANG Lixin XIA Chuanqin   作者單位： LI Yun,YANG Fan,XIA Chuanqin(Department of Chemistry,Sichuan University,Chengdu,Sichuan 610041,China)

XU Xiaoying,PAN Shiyin,WANG Lixin(Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province and National Engineering Research Center of Chiral Drugs,Chengdu Institute of Organic Chemistry,Chinese Academy of Sciences,Chengdu,Sichuan 610041,China) 

刊 名： 中國化學（英文版）  SCI 英文刊名： CHINESE JOURNAL OF CHEMISTRY  年，卷(期)： 2009 27(2)  分類號： O6  關鍵詞： preparation   tyramine   β-(p-hydroxyphenyl)propionic acid   curtius rearrangement  

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